Enfermedades del Sistema Nervioso » Nanoneurocirugía
Coordinador de Grupo
Alejandro Carrasco González
Doctor en Medicina
Profesor asociado/adjunto Unidad Docente Facultad de Medicina y Enfermería de la UPV/EHU, Dpto. Cirugía, Radiología y Medicina Física
OSI Eskerraldea Enkarterri Cruces
Contacto
(0034) 94 600 6000
Miembros del Grupo
Gaizka Bilbao Barandica
Guillermo Carbayo Lozano
Gregorio Catalan Uribarrena
Lara Galbarriatu Gutierrez
José Vicente Lafuente Sanchez
Iñigo Pomposo Gaztelu
Miren Edurne Ruiz de Gopegui Ruiz
Laura Zaldumbide Dueñas
Líneas de Investigación
Actividades del Grupo
Publicaciones Científicas

Sharma HS, Muresanu DF, Lafuente JV, Patnaik R, Tian ZR, Ozkizilcik A, et al. Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer's Disease. Mol. Neurobiol. 2018; 55(1): 300 - 311. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0742-9.

Sharma A, Muresanu DF, Lafuente JV, Sjoquist PO, Patnaik R, Tian ZR, et al. Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51. Mol. Neurobiol. 2018; 55(1): 276 - 285. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0740-y.

Caamano V, Zaldumbide L, Saiz M, Andres L, Nogueira A, Diaz I, et al. Correlation between vascular density with metastasis and poor prognosis in clear cell renal cell carcinoma with venous tumour thrombus: review of 39 cases. Virchows Arch. 2018; 473(1): 193 - 193. MEETING ABSTRACT.

Requejo C, Ruiz-Ortega JA, Bengoetxea H, Bulnes S, Ugedo L, Lafuente, JV. Deleterious Effects of VEGFR2 and RET Inhibition in a Preclinical Model of Parkinson's Disease. Mol. Neurobiol. 2018; 55(1): 201 - 212. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0733-x.

Aurtenetxe O, Zaldumbide L, Erramuzpe A, Lopez R, Lopez JI, Cortes JM, et al. DUSP5 expression associates with poor prognosis in human neuroblastoma. Exp. Mol. Pathol. 2018; 105(3): 272 - 278. FI: 2,566(Q2). DOI: 10.1016/j.yexmp.2018.08.008.

Bengoetxea H, Rico-Barrio I, Ortuzar N, Murueta-Goyena A, Lafuente J. Environmental Enrichment Reverses Tyrosine Kinase Inhibitor-Mediated Impairment Through BDNF-TrkB Pathway. Mol. Neurobiol. 2018; 55(1): 43 - 59. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0716-y.

Patnaik R, Sharma A, Skaper SD, Muresanu DF, Lafuente JV, Castellani RJ,et al. Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer's Disease. Mol. Neurobiol. 2018; 55(1): 312 - 321. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0743-8.

Zaldumbide L, Caamano V, Camin MS, Malaxetxebarria S, Velasco V, Solano JD, et al. Malignant ossifying fibromyxoid tumour with multiple recurrences in a child. Virchows Arch. 2018; 473(1): 154 - 154. MEETING ABSTRACT.

Martin-Guerrero I, Aurtenetxe O, Zaldumbide L, Astigarraga I, Hicks D, Schwalbe E, et al. Methylation profile in a retrospective series of spanish pediatric medulloblastoma. Neuro-Oncology. 2018; 20(2): 135 - 135. MEETING ABSTRACT.

Garcia-Ariza M, Aurtenetxe O, Martin-Guerrero I, Zaldumbide L, Astigarraga I, Llort A, et al. Molecular study in pediatric medulloblastoma. Validation of genetic markers in a national cohort of forty years. Neuro-Oncology. 2018; 20(2): 124 - 125. MEETING ABSTRACT.

Requejo C, Ruiz-Ortega JA, Cepeda H, Sharma A, Sharma HS, Ozkizilcik A, et al. Nanodelivery of Cerebrolysin and Rearing in Enriched Environment Induce Neuroprotective Effects in a Preclinical Rat Model of Parkinson's Disease. Mol. Neurobiol.. 2018; 55(1): 286 - 299. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0741-x.

Sharma A, Muresanu D, Lafuente J, Tian Z, Ozikzilcik A, Sharma H. Nanodelivery of Cerebrolysin With 5-HT6 Receptor Antagonist Induces Superior Neuroprotective Effects Following Concussive Head Injury Induced Exacerbation of Brain Pathology in Sleep Deprivation. J. Head Trauma Rehabil. 2018; 33(3): 76 - 76. MEETING ABSTRACT.

Saiz, M, Caamano, V, Zaldumbide, L, Idiondo, EFL, Munoz, AM, Mosteiro, L, Velasco, V, Malaxetxebarria, S, Gonzalez, M, Atienza, M, Nogueira, A, Parron, D, de Lezcano, ID, Lopez, JI. Negative Association Between PD1/PD-L1 Inhibitor Expression and ROS1, ALK and EGFR Mutations in Non-Small Cell Lung Cancer. Mod. Pathol. 2018; 31(2): 749 - 749. MEETING ABSTRACT.

Saiz, M, Caamano, V, Zaldumbide, L, Idiondo, EFL, Munoz, AM, Mosteiro, L, Velasco, V, Malaxetxebarria, S, Gonzalez, M, Atienza, M, Nogueira, A, Parron, D, de Lezcano, ID, Lopez, JI. Negative Association Between PD1/PD-L1 Inhibitor Expression and ROS1, ALK and EGFR Mutations in Non-Small Cell Lung Cancer. Lab. Invest. 2018; 98: 749 - 749. MEETING ABSTRACT.

Zaldumbide L, Aurtenetxe O, Erramuzpe A, Saiz M, Lopez-Almaraz R, Caamano V, et al. Neuroblastoma PTPome Analysis Unveils Association of PTPN1 And DUSP5 Expression With Poor Prognosis. Mod. Pathol. 2018; 31(2): 720 - 720. MEETING ABSTRACT.

Zaldumbide L, Aurtenetxe O, Erramuzpe A, Saiz M, Lopez-Almaraz R, Caamano V, et al. Neuroblastoma PTPome Analysis Unveils Association of PTPN1 And DUSP5 Expression With Poor Prognosis. Lab. Invest. 2018; 98: 720 - 720. MEETING ABSTRACT.

Zaldumbide L, Olabarria IV, Uribarrena GC, Munoz PC, Fernandez-Lomana E, Robles MA, et al. Pleomorphic pineocytoma, a mimicker of a high grade lesion. Virchows Arch. 2018; 473(1): 144 - 144. MEETING ABSTRACT.

Lafuente JV, Sharma A, Muresanu DF, Ozkizilcik A, Tian ZR, Patnaik R, et al. Repeated Forced Swim Exacerbates Methamphetamine-Induced Neurotoxicity: Neuroprotective Effects of Nanowired Delivery of 5-HT3-Receptor Antagonist Ondansetron. Mol. Neurobiol. 2018; 55(1): 322 - 334. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0744-7.

Muresanu D, Sharma A, Lafuente J, Tian Z, Ozikzilcik A, Sharma H. Repeated TiO2-Nanowired Delivery of Cerebrolysin Reduces Pathophysiology of Blast Brain Injury. J. Head Trauma Rehabil. 2018; 33(3): 75 - 76. MEETING ABSTRACT.

Murueta-Goyena A, Ortuzar N, Gargiulo PA, Lafuente JV, Bengoetxea H. Short-Term Exposure to Enriched Environment in Adult Rats Restores MK-801-Induced Cognitive Deficits and GABAergic Interneuron Immunoreactivity Loss. Mol. Neurobiol. 2018; 55(1): 26 - 41. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0715-z.

Saiz MA, Mosteiro L, Velasco V, Malaxetxebarria S, Caamano V, Gonzalez M, et al. Solitary fibrous tumour of the pleura: review of cases in a university hospital over the last twenty years. Virchows Arch. 2018; 473(1): 325 - 325. MEETING ABSTRACT.

Ozkizilcik A, Sharma A, Muresanu DF, Lafuente JV, Tian ZR, Patnaik R, et al. Timed Release of Cerebrolysin Using Drug-Loaded Titanate Nanospheres Reduces Brain Pathology and Improves Behavioral Functions in Parkinson's Disease. Mol. Neurobiol. 2018; 55(1): 359 - 369. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0747-4.

Feng LY, Sharma A, Niu F, Huang Y, Lafuente JV, Muresanu DF, et al. TiO2-Nanowired Delivery of DL-3-n-butylphthalide (DL-NBP) Attenuates Blood-Brain Barrier Disruption, Brain Edema Formation, and Neuronal Damages Following Concussive Head Injury. Mol. Neurobiol. 2018; 55(1): 350 - 358. FI: 5,076(Q1). DOI: 10.1007/s12035-017-0746-5.

Garamendi I, Acera M, Agundez M, Galbarriatu L, Marinas A, Pomposo I, et al. Cardiovascular autonomic and hemodynamic responses to vagus nerve stimulation in drug-resistant epilepsy. Seizure. 2017;45:56-60. FI:2,448(Q2). DOI:10.1016/j.seizure.2016.11.018.

Garcia-Ariza M, Echebarria Barona A, Lopez-Almaraz R, Adan Pedroso R, Bilbao Salcines N, Ricondo De Diego A, et al. Tumors of the central nervous system in the first year of life. One single institution experience. Pediatr Blood Cancer. 2017;64:462. FI:2,513(Q1). ABSTRACT

Garcia-Ariza M, Lopez-Almaraz R, Echebarria Barona A, Adan Pedroso R, Ojinaga Nino I, Ricondo De Diego A, et al. Experience of the management of central nervous system tumors in;children younger than 5 years-old in the last 15 years. Pediatr Blood Cancer. 2017;64:304. FI:2,513(Q1). ABSTRACT

Lafuente JV, Requejo C, Carrasco A, Bengoetxea H. Nanoformulation: A Useful Therapeutic Strategy for Improving Neuroprotection and the Neurorestorative Potential in Experimental Models of Parkinson's Disease. Int Rev Neurobiol. 2017;137:99-122. FI:2,699(Q3). DOI:10.1016/bs.irn.2017.09.003.

Murga I, Guillen V, Lafuente JV. Cerebral magnetic resonance changes associated with fibromyalgia syndrome. Med Clin. 2017;148:511-6. FI:1,125(Q3). DOI:10.1016/j.medcli.2017.01.034.

Pulido R, Nunes-Xavier C, Aurtenetxe O, Zaldumbide L, Erramuzpe A, Lopez R, et al. Neuroblastoma PTPome analysis unveils association of DUSP5 and PTPN1 expression with poor prognosis. Ann Oncol. 2017;28:57. FI:11,855(Q1). ABSTRACT

Requejo C, Ruiz-Ortega JA, Bengoetxea H, García-Blanco A, Herrán E, Aristieta A, et al. Morphological Changes in a Severe Model of Parkinson's Disease and Its Suitability to Test the Therapeutic Effects of Microencapsulated Neurotrophic Factors. Mol Neurobiol. 2017;54:7722-35. FI:6,190(Q1). DOI:10.1007/s12035-016-0244-1.

Villaverde VC, Vadillo MG, Gonzalez LM, Benito VV, Camin MS, Alvarez LA, et al. A curious case of chest rash: Cutaneous plasmocytosis, a case report. Virchows Arch. 2017;471:122-3. FI:2,848(Q2). ABSTRACT

Villaverde VC, Vadillo MG, Gonzalez LM, Camin MS, Benito VV, Alvarez LA, et al. Pancreatic mx diagnosis of Clear Renal Cell Carcinoma (CRCC) by fnab-eus-guided: Review of 2 cases. Virchows Arch. 2017;471:310. FI:2,848(Q2). ABSTRACT

Zaldumbide L, Caamano V, Malaxetxebarria S, Fernandez-Lomana E, Atienza M, Nogueira A, et al. Malignant TFE3-rearranged perivascular epithelioid cell neoplasm (PEComa) in the masticator space in a child. Virchows Arch. 2017;471:259. FI:2,848(Q2). ABSTRACT

Zaldumbide L, Fernandez-Lomana E, Atienza M, Nogueira A, Marcos A, de Casasola GG, et al. Alexander's disease: A case report. Virchows Arch. 2017;471:219-20. FI:2,848(Q2). ABSTRACT

Zaldumbide L, Fernandez-Lomana E, Atienza M, Nogueira A, Marcos A, de Casasola GG, et al. Infantile desmoplastic ganglioglioma, a case report. Virchows Arch. 2017;471:221. FI:2,848(Q2). ABSTRACT

Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, et al. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol. 2016;14:e1002466. FI:9,797(Q1). DOI:10.1371/journal.pbio.1002466.

Aurtenetxe O, Zaldumbide L, Martín-Guerrero I, Ayman G, García M, Navajas A. Spanish experience in pediatric medulloblastoma.17th International Symposium on Pediatric Neuro-Oncology. 2016;18:iii114-5. FI:7,786(Q1). ABSTRACT

Garcia-Blanco A, Bulnes S, Pomposo I, Carrasco A, Lafuente JV. Nestin+cells forming spheroids aggregates resembling tumorspheres in experimental ENU-induced gliomas. Histol Histopathol. 2016;31:1347-56. FI:2,025(Q2). DOI:10.14670/HH-11-763.

Gartziandia O, Herran E, Ruiz-Ortega JA, Miguelez C, Igartua M, Lafuente JV, et al. Intranasal Administration of Chitosan-Coated Nanostructured Lipid Carriers Loaded with GDNF Improves Behavioral and Histological Recovery in a Partial Lesion Model of Parkinson's Disease. J Biomed Nanotechnol. 2016;12:2220-30. FI:4,521(Q1). DOI:10.1166/jbn.2016.2313.

Iturri-Clavero F, Galbarriatu-Gutierrez L, Gonzalez-Uriarte A, Tamayo-Medel G, de Orte K, Martinez-Ruiz A, et al. "Low-field" intraoperative MRI:a new scenario, a new adaptation. Clin Radiol. 2016;71:1193-8. FI:2,478(Q2). DOI:10.1016/j.crad.2016.07.003.

Lafuente JV, Bermudez G, Camargo-Arce L, Bulnes S. Blood-Brain Barrier Changes in High Altitude. CNS Neurol. Disord.-Drug Targets. 2016;15:1188-97. FI:2,506(Q2). DOI:10.2174/1871527315666160920123911.

Lezcano E, Gómez-Esteban JC, Tijero B, Bilbao G, Lambarri I, Rodriguez O, et al. Long-term impact on quality of life of subthalamic nucleus stimulation in Parkinson's disease. J Neurol. 2016;263:895-905. FI:3,389(Q2). DOI:10.1007/s00415-016-8077-4.

Zaldumbide L, Erramuzpe A, Guarch R, Pulido R, Cortes JM, Lopez JI. Snail heterogeneity in clear cell renal cell carcinoma. BMC Cancer. 2016;16:194. FI:3,288(Q2). DOI:10.1186/s12885-016-2237-x.

Beccari S, Abiega O, Diaz-Aparicio I, Zaldumbide L, Galbarriatu L, Marinas A, et al. Microglial phagocytosis is impaired in chronic mouse and human MTLE and correlates with inflammation. Glia. 2015;63:132. FI:5,997(Q1). ABSTRACT

Galbarriatu L, Pomposo I, Aurrecoechea J, Marinas A, Agundez M, Gomez JC, et al. Vagus nerve stimulation therapy for treatment-resistant epilepsy: A 15-year experience at a single institution. Clin Neurol Neurosur. 2015;137:89-93. FI:1,198(Q3). DOI:10.1016/j.clineuro.2015.06.023.

Requejo C, Ruiz-Ortega JA, Bengoetxea H, Garcia-Blanco A, Herran E, Aristieta A, et al. Topographical Distribution of Morphological Changes in a Partial Model of Parkinson's Disease-Effects of Nanoencapsulated Neurotrophic Factors Administration. Mol Neurobiol. 2015;52:846-858. FI:5,397(Q1). DOI:10.1007/s12035-015-9234-y.

Salles L, Girones X, Lafuente JV. The motor organization of cerebral cortex and the role of the mirror neuron system. Clinical impact for rehabilitation. Med Clin (Barc). 2015;144:30-34. FI:1,267(Q2). DOI:10.1016/j.medcli.2013.12.013.

Zaldumbide L, Erramuzpe A, Guarch R, Cortés JM, López JI. Large (> 3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous. Virchows Arch. 2015;466:61-66. FI:2,613(Q2). DOI:10.1007/s00428-014-1673-8.

Fernández-Valle T, Guío Carrión L, Galbarriatu Gutiérrez L, Vilar Achabal B. Actinomyces meyeri brain abscess. Med Clin (Barc). 2014;143:331-2. FI: 1,417(Q2)

Garcia-Alonso I, Aizpurua JM, Herrero B, Etxebarria-Loizate N, Echevarria-Uraga JJ. Alpha(V) Beta(3) integrin-targeted iodinated-RGD peptide, as a molecular contrast agent. Br J Surg. 2014;101:4. FI: 5,542(Q1)

Herrán E, Requejo C, Ruiz-Ortega JA, Aristieta A, Igartua M, Bengoetxea H, et al. Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease. Int J Nanomed. 2014;9:2677-87. FI: 4,383(Q1)

Palomares T, García-Alonso I, San Isidro R, Méndez J, Alonso-Varona A. All-trans-retinoic acid counteract the tumor-stimulating effect of hepatectomy and increases survival of rats bearing liver metastases. J Surg Res. 2014;188:143-51. FI: 1,936(Q2)

Pomposo I, Ruiz de Gopegui E, Bilbao G, Carbayo G, Galbarriatu L, Garcia-Alonso I. Intraoperative imaging in neurosurgery: initial experience with CT-SCAN in deep brain stimulation and spine surgery. Br J Surg. 2014;101:10. FI: 5,542(Q1)

Herrán E, Ruiz-Ortega JÁ, Aristieta A, Igartua M, Requejo C, Lafuente JV, et al. In vivo administration of VEGF- and GDNF-releasing biodegradable polymeric microspheres in a severe lesion model of Parkinson's disease. Eur J Pharm Biopharm. 2013;85:1183-90. FI: 3,826(Q1)

Bengoetxea H, Ortuzar N, Rico-Barrio I, Lafuente JV, Argandona EG. Increased physical activity is not enough to recover astrocytic population from dark-rearing. Synergy with multisensory enrichment is required. Front Cell Neurosci. 2013;7:170. FI: 4,469(Q1)

Galbarriatu L, Rivero-Garvía M, Olivares M, Miranda D, Pomposo I, Márquez-Rivas J. Low-pressure hydrocephalus: indication for custom-made catheters? Technical report. Acta Neurochir. 2013;155:1981-5. FI: 1,546(Q2)

Rodriguez-Sainz A, Escalza-Cortina I, Guio-Carrion L, Matute-Nieves A, Gomez-Beldarrain M, Carbayo-Lozano G, et al .Intracerebral hematoma complicating herpes simplex encephalitis. Clin Neurol Neurosurg. 2013;115:2041-5. FI: 1,234(Q3)

Ortuzar N, Rico-Barrio I, Bengoetxea H, Argandona EG, Lafuente JV. VEGF reverts the cognitive impairment induced by a focal traumatic brain injury during the development of rats raised under environmental enrichment. Behav Brain Res. 2013;246:36-46. FI: 3,327(Q2)

Echevarria-Uraga JJ, Garcia-Alonso I, Herrero B, Marin H, Insausti M, Plazaola F, et al. Liver hyperthermia induced by different iron magnetic nanoparticles ``ex vivo'' and correlation to pathological damage in the tissue. Br J Surg. 2013;100:12. FI: 4,839(Q1). (Meeting Abstract).

Cearra I, Garcia-Alonso I, Ikutza A, Ferre T, Lobato E. New experimental model of ischemia-reperfusion syndrome in lower limbs. Br J Surg. 2013;100:10. FI: 4,839(Q1)

Blanco-Vidal MJ, Catalan-Urribarrena G, Lopez JI, del Aguila C, Magnet A, Pomposo-Gaztelu I, et al. Left-sided hemiparesis in a diabetic patient: chronic granulomatous encephalitis due to Acanthamoeba. Rev Neurologia. 2013;56:187-8. FI: 1,179(Q4)

Menon PK, Muresanu DF, Sharma A, Aguilar ZP, Wang YA, Lafuente JV, et al. Functionalized Magnetic Iron Oxide Nanoparticles Influence Spinal Cord Trauma-Induced Pathology: Neuroprotective Effects of Cerebrolysin Treatment. Cell Transplant. 2013;22:909. FI: 4,422(Q1). (Meeting Abstract).

Tesis

Autor/a: Catalina Requejo Rodríguez. Título: Morphofunctional changes in a rat model of Parkinson's disease, Effects of neurotrophic factors administration. Director/a: Dr. José Vicente Lafuente Sánchez. UPV/EHU

Autor/a: Ivan Aguirregoicoa Olabarrieta. Título: El spot sign y spot sign score en el hematoma cerebral espontáneo: aplicaciones clínicas en la urgencia de neuroradiología. Director/a: Dr. Ignacio García Alonso Montoya, Dr. Gerard Piñol Ripoll. UPV/EHU

Autor/a: Amador García Ruiz de Gordejuela. Título: Valoración crítica y estudio de la gastrectomía vertical como técnica quirúrgica bariátrica. Director/a: Dr. Ignacio García-Alonso Montoya. UPV/EHU